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醋酸奥曲肽(Octreotide acetate)是一种人工合成的类似生长抑素作用的八肽。最近,经美国FDA批准用于治疗转移性类癌,即分泌具有血管活性的肠肽瘤(VIPomas)。作用人体生长抑放素是由14个氨基酸组成的,半减期大约为1～3分钟,必须采用持续静脉输注。奥曲肽既保留了生长抑素分子中最基本的部分,而且还有2个能遏阻血清肽酶降解的D-氨基酸。其半减期约1.5小时,可经皮下注射。临床试验 25例恶性类癌患者,奥曲肽150μg,一天3次皮下注射,有22例(88%)面红和腹泻症状迅速缓解,少数肝功能检查
Octreotide acetate is a synthetic octapeptide that acts like somatostatin. Recently approved by the U.S. FDA for the treatment of metastatic carcinoids, secreted vasoactive intestinal peptideomas (VIPomas). Role of human somatostatin is composed of 14 amino acids, semi-reduction of about 1 to 3 minutes, must be used for continuous intravenous infusion. Octreotide retains the most basic part of the somatostatin molecule, and two D-amino acids stop the degradation of serum peptidase. The half-time of about 1.5 hours, can be injected subcutaneously. Clinical trial of 25 cases of malignant carcinoid patients, octreotide 150μg, 3 times a day subcutaneous injection, 22 cases (88%) of the redness and diarrhea symptoms relieve a small number of liver function tests