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目的以往研究表明,不同造影剂的使用量在造影剂肾病的发生中有着重要意义。本研究旨在分析比较不同使用量的碘普罗胺对于患者肾功能的损害情况。方法将252名脑血管病患者根据造影剂的使用量分为AB两组:A组≤150ml,B组>151ml。通过测量术前及术后24-48h的肌酐、肌酐清除率、尿素氮、尿酸以及胱抑素C等来观察肾功能的变化。结果 A组中cCr、BUN、UA以及B组中cCr、UA在造影术后的测定值与术前有统计学差异。11人sCr上升>基础值的25%,其中A组3例,B组8例,CIN发生率分别为2%和7.4%。结论使用造影剂对肾功能有一定的影响,并且大剂量造影剂的使用可以提高CIN的发病率,但是在56-245ml的剂量范围内与造影剂的使用量没有明显的相关性。
Purpose Previous studies have shown that the use of different contrast agents in the incidence of contrast agent nephropathy is of great significance. The aim of this study was to compare and analyze the impaired renal function of patients with different doses of iopromide. Methods 252 patients with cerebrovascular disease were divided into two groups according to the amount of contrast agent: group A ≤150ml, group B> 151ml. The changes of renal function were observed by measuring creatinine, creatinine clearance, urea nitrogen, uric acid and cystatin C before and 24-48 hours after operation. Results The values of cCr, UA in group C and UA in group A after operation were significantly different from those before operation. 11 people sCr rise> 25% of the basal value, including 3 cases in group A, 8 cases in group B, the incidence of CIN was 2% and 7.4% respectively. Conclusions The use of contrast media has some effect on renal function, and the use of high-dose contrast media may increase the incidence of CIN, but there is no significant correlation with the amount of contrast media in the range of 56-245ml.