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目的评价腺苷蛋氨酸联合熊去氧胆酸治疗老年戊肝的疗效和安全性。方法将72例老年戊肝患者随机分为两组,治疗组37例,对照组35例。对照组用常规药物治疗,治疗组在常规药物治疗的基础上加用腺苷蛋氨酸和熊去氧胆酸,疗程均为30d。观察两组治疗前后血清的总胆红素(TBil)、ALT、总胆汁酸(TBA)的水平,同时观察患者症状和体征的变化。结果治疗30d时,治疗组总有效率显著高于对照组(x2=7.720,P<0.01),TBil和TBA水平与对照组相比显著降低(P<0.01),而ALT水平与对照组相比,差异无统计学意义(t=0.061,P>0.05)。所有观察病例均无严重不良反应发生。结论腺苷蛋氨酸联合熊去氧胆酸治疗老年戊型肝炎是有效的、安全的。
Objective To evaluate the efficacy and safety of adenosine methionine combined with ursodeoxycholic acid in the treatment of elderly patients with hepatitis E. Methods Seventy-two elderly patients with hepatitis E were randomly divided into two groups: treatment group (37 cases) and control group (35 cases). Control group with conventional drug treatment, the treatment group on the basis of conventional drug therapy with adenosyl methionine and ursodeoxycholic acid, treatment were 30d. The levels of total bilirubin (TBil), ALT and total bile acid (TBA) in both groups were observed before and after treatment, and the changes of symptoms and signs were observed. Results At 30 days, the total effective rate in the treatment group was significantly higher than that in the control group (x2 = 7.720, P <0.01). The levels of TBil and TBA in the treatment group were significantly lower than those in the control group (P <0.01) , The difference was not statistically significant (t = 0.061, P> 0.05). No serious adverse reactions occurred in all observed cases. Conclusions Adenosine methionine combined with ursodeoxycholic acid is effective and safe for the treatment of hepatitis E in the elderly.