Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by a

• 作 者: Xuyang Wang Naoki Oishi Tetsur
• 机 构: DepartmentofDiseaseControlandHomeostasis,DepartmentofGastroenterology
• 出 处: 世界胃肠病学杂志：英文版
• 发表日期: 2017年18期
• 关键词: 肝炎 B 病毒 X 蛋白质 Hepatocellular 癌 KDM5B 祖先房间 TUMORIGENESIS Hepatitis B virus X prot
• 基金项目: Supported by Grant-in-Aid for Scientific Research(KAKENHI)(C),No.15K08992(to Oishi N),Core-to-Core Program,B.Asia-Africa Science Platforms,the Japan Society for the Promotion of Science(to Kaneko S)

AIM To determine the role of hepatitis B virus X protein(HBx), HBx in regulating hepatic progenitor cell(HPC)-like features in hepatocellular carcinoma(HCC) and the underlying molecular mechanisms.METHODS We used a retrovirus vector to introduce wild type