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树突状细胞（ＤＣ）是目前体内功能最强的专职抗原递呈细胞，具有加工处理递呈抗原并直接激活处女Ｔ细胞、诱导Ｔ细胞免疫应答的功能。慢性髓系白血病表达的Ｐ２１０ＢＣＲＡＢＬ融合蛋白能够被ＤＣ加工处理，降解产生的具有免疫原性的融合区肽，以一定的构型和足够高的浓度与ＭＨＣⅡ分子结合，刺激抗原特异性Ｔ细胞发生反应。由于Ｐ２１０ＢＣＲＡＢＬ融合蛋白广泛存在于９５％以上的ＣＭＬ病人，对细胞的恶性转化及恶性表型的维持至关重要。因而，Ｐ２１０ＢＣＲＡＢＬ融合区肽负载的ＤＣ将成为ＣＭＬ生物治疗的有效手段。
Dendritic cells (DCs) are the most powerful professional antigen presenting cells in the body. They have the functions of processing and presenting antigens and directly activating virgin T cells and inducing T cell immune responses. The P210BCR-ABL fusion protein expressed in chronic myeloid leukemia can be processed by DC, degraded to produce an immunogenic fusion domain peptide, binds to MHCII molecules with a certain configuration and high enough concentration to stimulate antigen-specific T cells. react. Since the P210BCR-ABL fusion protein is widely present in more than 95% of CML patients, it is essential for the malignant transformation of cells and the maintenance of malignant phenotypes. Therefore, P210BCR-ABL fusion peptide loaded DC will become an effective means of CML biotherapy.