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作者选择46例口腔和咽部鳞状细胞癌在接受口、咽部放疗的患者,调查记录其临床症状和特征,健康状况,吸烟习惯,义齿情况,在放疗前、放疗中、放疗后行真菌培养,以研究头颈部放疗者口腔念珠菌定居情况,及其对抗真菌治疗的反应,念珠菌的种类,并评价吸烟和义齿对它的影响。 结果发现:所有患者均有进行性的口腔干燥症状,放疗前念珠菌菌落形成单位阳性者为43％,放疗后为62％,随访时为75％,增加显著(P<0.0001)。有8例发生念珠菌病,虽然5例对抗真菌治疗(酮康唑和氟康唑)有效,但临床症状消失后,念珠菌培养仍为阳性;放疗前吸烟和不吸烟者阳性率分别为40％和44％,放疗后分别为80％和56％(P=0.09);有义齿和无义齿者放疗前分别为45％和43％,放疗后分别为73％和58％(P=0.42)。培养出的主要为白色念珠菌,其次有近平
The authors selected 46 patients with oral and pharyngeal squamous cell carcinomas who underwent oral and pharyngeal radiotherapy to investigate their clinical symptoms and characteristics, health status, smoking habits, and dentures, and prior to radiotherapy, radiotherapy, and radiotherapy. Culture to study the oral Candida colonization of head and neck radiotherapy, its response to antifungal treatment, the type of Candida, and the effect of smoking and denture on it. The results showed that all patients had progressive dry mouth symptoms. 43% of the patients were positive for Candida colony forming units before radiotherapy, 62% after radiotherapy, and 75% for follow-up, which increased significantly (P<0.0001). There were 8 cases of candidiasis, although 5 cases of antifungal treatment (ketoconazole and fluconazole) were effective, but after the disappearance of clinical symptoms, Candida culture was still positive; the prevalence of smoking and non-smokers before radiotherapy was 40 % and 44% were 80% and 56% after radiotherapy (P=0.09); dentures and non-sense tooth were 45% and 43% before radiotherapy, respectively, 73% and 58% after radiotherapy (P=0.42) . The main strain cultivated was Candida albicans, followed by Jinping