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肿瘤坏死因子(TNF)是细菌侵入机体发生全身性反应的中心介导物质。急性给予足够剂量的TNF可造成休克、酸中毒、乳酸血症乃至死亡。本文作者通过注射亚致死剂量的TNF,研究脾脏及环氧合酶
Tumor necrosis factor (TNF) is a central mediator of bacterial systemic intrusion into the body. Acute administration of adequate doses of TNF can cause shock, acidosis, lactic acidosis and even death. The authors investigated spleen and cyclooxygenase by injecting sub-lethal doses of TNF