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目的根据ERP理论和韦氏智力量表内容建立数字计算ERP范式,探讨正常人与重型颅脑损伤患者数字计算ERP特征及与智商的相关性。方法采用Neuroscan-ERP仪和韦氏智力量表对29名重型颅脑损伤患者(外伤组)和46名正常人(对照组)进行ERP及智商检测,比较引出的ERP成分特征及与智商的相关性。结果数字计算范式的题目、正确、错误答案3类刺激引出的ERP波形包括外源性成分N1c、P2c及内源性成分N2c和P3c;对照组引出的N1c和P2c波幅和潜伏期相近,但N2c和P3c有明显差异,其中正确答案的P3c波幅最高,错误答案的P3c潜伏期最长;外伤组引出的各ERP成分波幅降低、潜伏期延长,N2c和P3c具有显著性差异(P<0.05);对照组错误答案引出的P3c潜伏期与言语智商和总智商呈中度负相关,高于题目和正确答案;外伤组P3c潜伏期与言语智商、操作智商和总智商的相关系数分别为-0.64、-0.46和-0.60(P<0.05),明显高于对照组。结论数字计算ERP范式可引出特征性ERP波形,其P3c潜伏期与智商有一定相关性,可作为评价重型颅脑损伤后数学能力损害程度的参考指标。
Objective To establish a digital computing ERP paradigm based on the ERP theory and Webster Intelligence Scale, and to explore the characteristics of digital computing ERP and its relationship with IQ in normal subjects and patients with severe craniocerebral injury. Methods 29 cases of severe traumatic brain injury (trauma group) and 46 normal persons (control group) were detected by ERP and IQ by using Neuroscan-ERP and Webster’s Intelligence Scale. The ERP components and the correlation with IQ Sex. The results of the numerical calculation paradigm of the problem, correct and wrong answer 3 types of stimulation leads to the ERP waveform includes exogenous components N1c, P2c and endogenous components N2c and P3c; control group derived N1c and P2c amplitude and latency similar, but N2c and P3c had the obvious difference, the correct answer had the highest amplitude of P3c, the wrong answer had the longest latency of P3c; the amplitude of each ERP component induced by trauma decreased, the latent period prolonged, N2c and P3c had significant difference (P <0.05); The P3c latent period leads to a moderate negative correlation with speech IQ and total IQ, which is higher than that of the subject and the correct answer. The correlation coefficients of latent period of P3c and speech IQ, operational IQ and total IQ of trauma group are -0.64, -0.46 and -0.60 (P <0.05), which was significantly higher than that of the control group. Conclusions The numerical calculation of ERP paradigm can lead to a characteristic ERP waveform. The P3c latency has some correlation with IQ, which can be used as a reference index to evaluate the degree of impairment of mathematical ability after severe craniocerebral injury.