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目的探讨动脉粥样硬化(AS)患者同型半胱氨酸(Hcy)与纤溶活性的关系。方法根据颈动脉彩超检查结果分为AS不稳定性斑块组、稳定性斑块组和正常对照组,分别测定Hcy、组织型纤溶酶原激活物(t-PA)、组织型纤溶酶原抑制物(PAI)等。结果不稳定斑块组、稳定斑块组Hcy、PAI较正常对照组增高,t-PA降低(P<0.05);而不稳定斑块组Hcy、PAI增高,t-PA降低更明显;从相关性分析看AS组Hcy与PAI呈正相关(P<0.05)、与t-PA呈负相关(P<0.05)。结论AS患者Hcy增高的同时,纤溶活性受损;Hcy与PAI呈正相关、与t-PA呈负相关。
Objective To investigate the relationship between homocysteine (Hcy) and fibrinolytic activity in patients with atherosclerosis (AS). Methods According to the result of carotid ultrasonography, AS unstable plaque group, stable plaque group and normal control group were divided into three groups: Hcy, tissue plasminogen activator (t-PA), tissue plasminogen The original inhibitor (PAI) and so on. Results The levels of Hcy and PAI in unstable plaque group and stable plaque group were higher than those in normal control group and decreased in t-PA (P <0.05), while the levels of Hcy and PAI in unstable plaque group were higher than those in control group Sex analysis showed that Hcy in AS group was positively correlated with PAI (P <0.05) and negatively correlated with t-PA (P <0.05). Conclusions Hcy increased in AS patients with impaired fibrinolytic activity. Hcy was positively correlated with PAI and negatively correlated with t-PA.