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本文旨在分析肝脏腺鳞癌(ASC)的临床病理特征,检测角蛋白(CK)在其腺癌(AC)和鳞癌(SCC)成分中的表达,以阐释ASC的组织发生。 8例经病理确诊的ASC病人,6例行手术,2例行尸检。用抗CK7、8、18、19、903的单克隆抗体做免疫组化染色,分析临床病理特征。 8例中男6例,女2例,年龄48～69岁(平均60.6岁)。7例有腹痛、恶心、发热症状。HBsAg均阴性。HCVAb在3例所检病人均阴性。术前在7例所检病人AFP均阴性,CEA均阳性。有6例CA19-9阳性,鳞癌相关抗原在2例阳性。手术方式分别为扩大肝左叶切除1例,左叶切除1例,右叶切除1例,左外侧段切除3例。
This article aims to analyze the clinicopathological features of adenosquamous carcinoma of the liver (ASC) and detect the expression of keratin (CK) in its adenocarcinoma (AC) and squamous cell carcinoma (SCC) components to elucidate the histogenesis of ASC. Eight patients with ASC diagnosed by pathology underwent surgery in 6 cases and autopsy in 2 cases. Anti-CK7, 8, 18, 19, and 903 monoclonal antibodies were used for immunohistochemical staining to analyze the clinicopathological features. In 8 cases, there were 6 males and 2 females, aged 48-69 years (average 60.6 years). Seven patients had abdominal pain, nausea, and fever. HBsAg was negative. HCVAb was negative in all 3 patients tested. Preoperative AFP was negative in 7 patients and CEA was positive. There were 6 cases of CA19-9 positive, and squamous cell carcinoma associated antigen was positive in 2 cases. The surgical methods included enlargement of the left hepatectomy in 1 case, left lobectomy in 1 case, right lobectomy in 1 and left lateral resection in 3 cases.