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目的 :探讨高压氧 (HBO)对急性缺血性脑中风的治疗价值及机理。方法 :对 40例脑梗塞患者予以HBO加尼莫地平治疗 (HBO组 ) ,40例脑梗塞患者予以尼莫地平加甘露醇治疗 (药物组 ) ,于治疗前后检测红细胞变形指数 (DI)、球结膜微循环 (BCM )、经颅多普勒超声 (TCD)的改变 ,进行对比分析。结果 :HBO组治疗后BCM改善显著 (P <0 .0 1) ,DI明显增强 (P <0 .0 1) ,但TCD无明显变化 (P >0 .0 5 )。药物组治疗后BCM、DI及TCD均较治疗前明显改善 (P <0 .0 5 ) ,BCM、TCD与HBO组比较有明显差异 (P <0 .0 5 )。DI和临床神经功能缺损疗效评价 ,HBO组与药物组比较无显著差异 (P >0 .0 5 )。结论 :HBO在治疗缺血性脑中风方面并不优越于常规药物的疗效 ,它具有双重性 ,既有有利的一面 ,也存在不利的影响 ,必须适当选择适应症 ,并应与扩血管药、钙离子拮抗剂联合使用以对抗其不利的影响 ,有利于缺血脑中风的治疗及康复。
Objective: To investigate the therapeutic value and mechanism of hyperbaric oxygen (HBO) on acute ischemic stroke. Methods: Forty cerebral infarction patients were treated with HBO plus nimodipine, 40 patients with cerebral infarction were treated with nimodipine plus mannitol (drug group), and the indexes of erythrocyte deformability (DI), ball Conjunctival microcirculation (BCM), transcranial Doppler ultrasound (TCD) changes, comparative analysis. Results: The improvement of BCM in HBO group was significant (P <0.01), DI was significantly increased (P <0.01), but there was no significant change in TCD (P> 0.05). BCM, DI and TCD in the drug group were significantly improved after treatment (P <0. 05), BCM, TCD and HBO group were significantly different (P <0. DI and clinical neurological deficit evaluation, there was no significant difference between the HBO group and the drug group (P> 0.05). Conclusion: HBO is not superior to conventional drugs in the treatment of ischemic stroke. It has duality, which has advantages and disadvantages as well as adverse effects. Indications should be appropriately selected and should be used in combination with vasodilators, Calcium antagonists combined to combat its adverse effects, is conducive to ischemic stroke treatment and rehabilitation.