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目的观察血管紧张素转换酶抑制剂(ACEIs)对中国原发性高血压患者血浆肾素活性(PRA)水平的影响。方法用放射免疫法检测188例原发性高血压患者的PRA,其中使用ACEIs的有101例,未使用ACEIs的有87例,比较两组间PRA的差异,分析ACEIs对患者PRA水平的影响。结果在整体分析中,ACEIs组PRA水平要高于对照组,其差异有统计学意义(0.99±1.24 nmol/(L.h)vs 0.61±0.86nmol/(L.h),P=0.018)。亚组分析显示,在女性高血压患者中,ACEIs组PRA水平要高于对照组,其差异有统计学意义(1.06±1.41 nmol/(L.h)vs 0.54±0.83 nmol/(L.h),P=0.036);但在男性高血压患者中,ACEIs组PRA水平与对照组相比无统计学差异(0.90±0.98 nmol/(L.h)vs 0.68±0.89 nmol/(L.h),P=0.281)。结论 ACEIs能升高女性原发性高血压患者PRA水平。
Objective To investigate the effects of angiotensin converting enzyme inhibitors (ACEIs) on plasma renin activity (PRA) in Chinese patients with essential hypertension. Methods Radioimmunoassay was used to detect PRA in 188 patients with essential hypertension. Among them, 101 patients were using ACEIs and 87 patients were not using ACEIs. The difference of PRA between the two groups was analyzed and the effect of ACEIs on PRA was analyzed. Results In the overall analysis, PRA levels in ACEIs group were significantly higher than those in control group (0.99 ± 1.24 nmol / (L.h) vs 0.61 ± 0.86 nmol / (L.h), P = 0.018). Subgroup analysis showed that PRA levels in ACEIs group were significantly higher than those in control group (1.06 ± 1.41 nmol / (Lh) vs 0.54 ± 0.83 nmol / (Lh), P = 0.036 ). However, there was no significant difference in PRA levels between ACEIs and controls (0.90 ± 0.98 nmol / (Lh) vs 0.68 ± 0.89 nmol / (Lh), P = 0.281) in men with hypertension. Conclusion ACEIs can increase PRA in women with essential hypertension.