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目的探讨肺隐球菌病的临床特点,提高医务人员对肺隐球菌病的临床诊疗能力。方法回顾性分析东莞市人民医院35例确诊为肺隐球菌病患者的临床症状、胸部影像和治疗情况。结果 35例肺隐球菌患者中,19例(54.3%)无明显基础疾病;29例(82.9%)的临床症状主要表现为咳嗽、咳痰等;影像学表现为肺单发或多发结节肿块影(11例,31.4%),或渗出实变影(12例,34.3%),或两种病灶混合存在(12例,34.3%);19例患者红细胞沉降率升高;13例患者白细胞轻度增高;2例患者无法判断疗效,其余病情均有好转。结论肺隐球菌病的临床症状与影像学表现无特征性,确诊需依靠病理活检,经皮肺穿刺活检是有效的诊断手段。
Objective To investigate the clinical features of pulmonary cryptococcosis and to improve the medical diagnosis and treatment of pulmonary cryptococcosis. Methods Retrospective analysis of Dongguan City People ’s Hospital in 35 patients diagnosed as pulmonary cryptococcosis clinical symptoms, chest imaging and treatment. Results Of the 35 patients with pulmonary cryptococcosis, 19 (54.3%) had no obvious underlying diseases. The clinical symptoms of 29 patients (82.9%) mainly manifested as cough and expectoration. The imaging findings were single or multiple pulmonary nodules (11 cases, 31.4%) or exudation consolidation (12 cases, 34.3%), or a combination of both lesions (12 cases, 34.3%); 19 cases of erythrocyte sedimentation rate increased; 13 cases of leukocytes Mild increase; 2 patients can not determine the efficacy, the rest of the condition has improved. Conclusion The clinical symptoms and imaging manifestations of pulmonary cryptococcosis are characteristic. It is necessary to rely on biopsy for pathological diagnosis and percutaneous pulmonary biopsy is an effective diagnostic method.