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儿童和成人无论在身高体重还是在病理生理方面都有很大差异。一些研究证实体外循环(CPB)g寸甲状腺素有明显的抑制作用。但以往的研究对象大多是成人,对儿童这方面的问题知之甚少。本研究着重观察成人和儿童三碘甲腺原氨酸(T3)、四碘甲腺原氨酸(T4)在CPB中的变化,以掌握其变化规律。 1 材料和方法 11例儿童(年龄5.3±1.2岁,体重15.2±2.3kg),病种包括房、室间隔缺损等。10例成人(年龄36.2±8.1岁,体重55.9±11.3 kg),病种主要为做瓣膜替换术的瓣膜病。芬太尼、安氟醚复合麻醉,Sarns体外循环机,鼓泡式或膜式氧合器,低温平流灌注。抽标本时间为:CPB前、CPB早期、CPB晚期、CPB后。T_3、T_4用特异性的放射性免疫方法。数据用±s表示,用配对t检验或成组t检验。变化趋势以CPB前为参照值,用百分比来表达。用SPSS统计软件处理,P<0.05有统计意义。
Children and adults vary widely in height, weight, and pathophysiology. Some studies have confirmed that extracorporeal circulation (CPB) g thyroid hormone significantly inhibited. However, most of the previous research subjects were adults, and little was known about children’s problems in this respect. This study focused on the observation of the changes of triiodothyronine (T3) and tetraiodothyronine (T4) in CPB in adults and children, in order to understand its variation. 1 Materials and Methods 11 cases of children (age 5.3 ± 1.2 years old, body weight 15.2 ± 2.3kg), including the types of diseases, ventricular septal defect. 10 adults (age 36.2 ± 8.1 years, weight 55.9 ± 11.3 kg), the disease is mainly used for valve replacement valvular disease. Fentanyl, enflurane combined anesthesia, Sarns cardiopulmonary bypass, bubble or membrane oxygenator, hypothermia perfusion. Pumping time: before CPB, early CPB, late CPB, after CPB. T_3, T_4 with specific radioimmunoassay method. Data with ± s said, using paired t-test or group t test. The trend is based on the value before CPB and is expressed as a percentage. SPSS statistical software, P <0.05 was statistically significant.