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在药物控制释放系统中,药物能够按照设计的剂量在要求的时间范围内以均匀速率持续释放,达到低剂量、高疗效的效果.利用天然或合成的聚合物作为药物载体或介质来构建药物控制释放系统可以有效地降低药物的毒副作用,减少患者耐药性,提高药物的稳定性和生物利用度.环糊精和聚合物可以通过疏水力、氢键、范德华力等驱动力相互作用形成环糊精(准)聚轮烷,因其具有独特的结构、良好的生物相容性、易于化学修饰以及环糊精在聚合物轴上可迁移等特点.既可以将药物包结在环糊精(准)聚轮烷中的环糊精空腔中,也可以将药物键合在环糊精外侧的羟基上,从而可以增大药物载药量、溶解性以及稳定性.环糊精(准)聚轮烷药物控制释放系统可以有效地将环糊精的包结、易修饰技术和聚合物纳米给药技术融合一体,使药物能够达到定点、定时以及定量的释放效果.然而,到目前为止,基于环糊精(准)聚轮烷构建的药物控制释放系统大多只停留在体外实验研究阶段,需要加快其相关理论以及其在生物体内的研究进度,从而获得具有更高的载药量和包封率、更好的药物控制释放效率和真正能适用于生物体内的新型环糊精(准)聚轮烷药物控制释放体系.本文综述了近年来基于环糊精(准)聚轮烷构建的药物控制释放系统在药物控制释放中的应用的最新研究进展,并对其发展作了进一步的展望.
In drug controlled release systems, the drug can be sustainedly released at a uniform rate over the required timeframe at the designed dose to achieve a low dose, high curative effect.Consolidation of drug control using natural or synthetic polymers as drug carriers or mediators Release system can effectively reduce the drug side effects, reduce patient drug resistance and improve the stability and bioavailability of drugs.Cyclodextrin and polymer can form a ring by the driving force of hydrophobic, hydrogen bonding, van der Waals forces and other interactions Dextrin (quasi) polyrotaxane, because of its unique structure, good biocompatibility, easy chemical modification and cyclodextrin can be migrated on the polymer axis and so on.Not only can the drug inclusion in cyclodextrin (Quasi) polyrotaxane cyclodextrin cavity, the drug can also be bonded to the hydroxyl on the outside of the cyclodextrin, which can increase drug loading, solubility and stability of cyclodextrin (quasi) ) Polyrotaxane drug controlled release system can effectively encapsulate cyclodextrin, easy modification technology and polymer nano-drug delivery technology integration, so that drugs can be sentinel, timing and quantitative release effect However, until now, drug controlled release systems based on cyclodextrin (quasi-) polyrotaxane have mostly stayed in the experimental phase of in vitro studies and need to speed up their related theories and research progress in vivo so as to obtain a more controlled drug delivery system with more High drug loading and entrapment efficiency, better drug release rate control, and a novel cyclodextrin (quasi) polyrotaxane drug release system that can be applied to the organism in vivo.This paper reviews the recent advances in the drug delivery system based on cyclodextrin Quasi) polyrotaxane drug controlled release system in drug controlled release of the latest research progress, and made its further development prospects.