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为了探讨硝苯吡啶临床使用量是否使心功能降低和能否由于扩张末梢血管而减轻心功不全时的后负荷,在临床中,对心功不全患者单独口服该药后心功能显著改善。作者应用硝苯吡啶和消心痛对轻、中度心功不全患者进行血液动力学的研究,其结果确实有减轻心功不全的后负荷作用。一、心功能不全的血液动力学改变当心功能不全、心搏出量减少时,交感神经兴奋,尤其是肾血流量减少,近端肾小管的钠和水再吸收增加,静脉回流增加,静脉压上升。另外,肾素分泌增加,血管紧张素Ⅰ增加,转变成血管紧张素Ⅱ,醛固酮分泌亢进,引起远端肾小管水,钠吸收增加。
In order to investigate whether the clinical use of nifedipine decreases cardiac function and whether it can reduce the post-load of cardiac insufficiency due to the expansion of peripheral blood vessels, in patients with cardiac insufficiency, the heart function of the patients with cardiac insufficiency alone after oral administration of the drug is significantly improved. The authors applied nifedipine and nocturnal relief to patients with mild to moderate cardiac insufficiency for hemodynamic studies, the results do have to reduce after-effects of cardiac insufficiency. First, cardiac insufficiency hemodynamic changes Beware of dysfunction, reduced cardiac output, sympathetic excitation, especially renal blood flow decreased proximal tubular sodium and water reabsorption increased venous return increased venous pressure rise. In addition, increased renin secretion, increased angiotensin I, converted to angiotensin II, hyperaldosteronism, causing distal tubular water, increased sodium absorption.