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目的 探讨胃肠三叶蛋白(PS2) 在胃癌及癌前病变的表达及其与淋巴结转移的关系。方法 免疫组化SP法测定正常胃黏膜(NOR)、萎缩性胃炎伴中重度肠化(IM)、萎缩性胃炎伴中重度不典型增生(DYS)和早期胃癌(EGC) 各40例, 进展期胃癌(AGC) 100 例中PS2 的表达。结果 NOR、IM、DYS、EGC和AGC组中, 分别有100%、80 0%、75 5%、40 0%和65 0%PS2阳性。PS2表达从IM、DYS至EGC组渐低, AGC高于EGC组。AGC组中, PS2表达在弥漫型高于肠型; PS2表达在浸润胃壁全层及浆膜外者和伴淋巴结转移者中高于仅及肌层者和无转移者; 且与患者性别、年龄、肿瘤部位和大小无关。PS2 对AGC淋巴结转移阳性预测值为0 692。结论 PS2蛋白表达与胃癌发生发展有关, 可用于判定其淋巴结转移。
Objective To investigate the expression of gastrointestinal trefoil protein (PS2) in gastric carcinoma and precancerous lesions and its relationship with lymph node metastasis. Methods The normal gastric mucosa (NOR), atrophic gastritis with moderate to severe intestinal metaplasia (IM), atrophic gastritis with moderate to severe atypical hyperplasia (DYS) and early gastric cancer (EGC) were determined by immunohistochemical SP method. Expression of PS2 in 100 cases of gastric cancer (AGC). Results In NOR, IM, DYS, EGC and AGC groups, 100%, 80%, 75%, 40% and 65% PS2 were positive. PS2 expression decreased from IM, DYS to EGC group, AGC higher than EGC group. In the AGC group, the expression of PS2 in diffuse type was higher than that in intestinal type. The expression of PS2 was higher in infiltrating gastric full-thickness and extra-serous than in those with lymph node metastasis than in those with only myometrial and without metastasis. Tumor site and size has nothing to do. The positive predictive value of PS2 for AGC lymph node metastasis was 0 692. Conclusion The expression of PS2 protein is related to the occurrence and development of gastric cancer and can be used to determine the lymph node metastasis.