论文部分内容阅读
目的观察舒郁胶囊对血管性抑郁模型大鼠行为学及脑组织单胺类神经递质的影响。方法采用高脂饲养结合慢性轻度不可预见性应激刺激建立大鼠血管性抑郁模型。将实验大鼠随机分为正常组、模型组、舒郁胶囊组、氟西汀组,并给予相应的干预措施。观察大鼠干预前后行为学评分及检测大鼠脑内5-HT、NE、DA含量变化。结果与正常组比较,模型组、舒郁胶囊组、氟西汀组大鼠的水平运动和垂直运动显著减少、糖水偏嗜度明显下降(P<0.01),脑组织内5-HT、NE、DA含量显著减少(P<0.01)。与模型组比较,舒郁胶囊组和氟西汀组大鼠的水平运动和垂直运动显著增加、糖水偏嗜度明显升高(P<0.05,P<0.01),脑组织内5-HT、NE、DA含量显著增加(P<0.05,P<0.01);但两组之间各项目无显著性差异(P>0.05)。结论舒郁胶囊具有抗血管性抑郁作用,其作用机制与增加脑组织内神经递质含量有关。
Objective To observe the effect of Shuyu capsule on behavior and monoamine neurotransmitter in brain tissue of rats with vascular depression. Methods A rat model of vascular depression was established by feeding with high fat and chronic mild unpredictable stress. The rats were randomly divided into normal group, model group, Shuyu capsule group and fluoxetine group, and the corresponding interventions were given. The behavioral score and the contents of 5-HT, NE and DA in rat brain were observed before and after the intervention. Results Compared with normal group, the level of motion and vertical movement of model group, Shuyu capsule group and fluoxetine group were significantly decreased, and the degree of glycemic index was significantly decreased (P <0.01). The levels of 5-HT, NE, DA content decreased significantly (P <0.01). Compared with the model group, the rats in Shuyu capsule group and fluoxetine group had significantly increased horizontal motion and vertical motion, and the degree of glyco-hydrophobia increased significantly (P <0.05, P <0.01). The levels of 5-HT, NE , DA content increased significantly (P <0.05, P <0.01), but there was no significant difference between the two groups (P> 0.05). Conclusion Shuyu capsule has anti-vascular depression, and its mechanism of action is related to increasing neurotransmitter content in brain tissue.