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有学者报告恶性肿瘤时血清淀粉样 A 蛋白(SAA)升高,可作为诊断肿瘤的一个标记;另有学者报道,SAA 浓度升高与各种实体瘤的远位转移呈正相关。SAA 在体内的作用尚不清楚。体外实验表明 SAA 可抑制鼠脾细胞对抗体的反应,亦可抑制人周围血淋巴细胞(PBL)对 T 细胞依赖性抗原的反应,这大概是通过T 细胞～巨噬细胞相互作用介导的,说明 SAA 在癌患者的免疫抑制中起一定作用。作者对肺癌患者作前瞻性研究,在确定肺癌诊断时测定 SAA 浓度,并考核其与周围血淋巴细胞数,对有丝分裂原(如 PHA、ConA)的反应、肿瘤扩散情况和生存期的关系。
Some scholars have reported that serum amyloid A protein (SAA) is elevated in malignant tumors and can be used as a marker for diagnosing tumors. Another scholar has reported that elevated SAA concentration is positively correlated with distant metastasis of various solid tumors. The role of SAA in the body is not yet clear. In vitro experiments show that SAA can inhibit the response of mouse spleen cells to antibodies, and can also inhibit the response of peripheral blood lymphocytes (PBL) to T cell-dependent antigens, which is probably mediated by T cell-macrophage interactions. This suggests that SAA plays a role in the immunosuppression of cancer patients. The authors performed a prospective study on lung cancer patients to determine the concentration of SAA in determining the diagnosis of lung cancer, and to assess its relationship with the number of peripheral blood lymphocytes, the response to mitogens (such as PHA, ConA), tumor proliferation and survival.