特异性染色体异常与人乳腺癌、肾癌和结肠-直肠癌的遗传因素

• 作 者: Pathak P Goodacre A 苏长林
• 出 处: 国外医学.遗传学分册
• 发表日期: 1987年04期
• 关键词: 人乳腺癌 实体瘤 染色体异常 染色体缺失 结肠肿瘤 染色体结构 乳腺癌细胞 乳腺肿瘤 肾细胞癌 淋巴瘤

在人类和动物的肿瘤中,约有98%出现染色体结构、数目或二者兼有的异常,这证明肿瘤转化是由于正常细胞的遗传物质改变所致。最初的特异性染色体异常—在慢性粒细胞白血病中发现Ph形式的G组染色体缺失和易位—为以后研究与肿瘤有关的特异性染色体异常奠定了基础。从这一发现以来,在白血病和淋巴瘤相继有许多报告,但在实体瘤则进展较为缓慢。只是在近几年,才有较多有关实体瘤染色体异常的报告。

About 98% of human and animal tumors have abnormal chromosome structures, numbers, or both, which proves that tumor transformation is due to changes in the genetic material of normal cells. The initial specific chromosomal abnormalities—the Ph-type chromosomal deletions and translocations in Ph form in chronic myelogenous leukemia—were laid the groundwork for future studies of tumor-specific chromosomal abnormalities. Since this discovery, there have been many reports in leukemia and lymphoma, but progress has been slower in solid tumors. Only in recent years have more reports on chromosomal abnormalities in solid tumors.