Zika virus infection, transmission, associated neurological disorders and birth abnormalities: A rev

• 作 者: Yitades Gebre Nikkiah Forbes Teshome Gebre
• 机 构: Pan American Health Organization/World Health Organization,Country Office,National HIV/AIDS and Infe
• 出 处: Asian Pacific Journal of Tropical Biomedicine
• 发表日期: 2016年10期
• 关键词: neurological transmission Aedes birth congenital autoimmune pathogenesis transfu

On February 1, 2016, the World Health Organization declared that the cluster of microcephaly cases and other neurological disorders constitute public health emergency of international concern. Furthermore, few studies demonstrated that there was an increased evidence of causal relationship of Zika virus(ZIKAV) infection and microcephaly, birth abnormalities and neurological disorders such as Guillain–Barre′ syndrome.ZIKAV transmission occurs mainly by the bite of infected mosquitos(Aedes species), but there are also reports that infections could occur via the placenta, breast milk, saliva,blood transfusion and sex. This article reviews the global efforts, progress in scientific research to understand the pathogenesis of ZIKAV infection & disease, clinical presentations, congenital transmission and autoimmune neurological disorders. The paper further explores the knowledge gaps, future priority research agenda for strategic response including vector control and prevention. We conducted a systematic literature review to synthesise available evidence on ZIKAV infection and its vector and host interaction from electronic databases.

On February 1, 2016, the World Health Organization declared that the cluster of microcephaly cases and other neurological disorders constitute public health emergency of international concern. Furthermore, few studies said that there was an increased evidence of causal relationship of Zika virus (ZIKAV) infection. and microcephaly, birth abnormalities and neurological disorders such as Guillain-Barre ’syndrome. ZIKAV transmission occurs mainly mainly by the bite of infected mosquitos (Aedes species), but there are also reports that infections could occur via the placenta, breast milk, saliva, blood The paper further explores the knowledge gaps, future priority research agenda for strategic response including vector control and prevention. We conduc ted a systematic literature review to synthesise available evidence on ZIKAV infection and its vector and host interaction from electronic databases.