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目的分析广西武鸣县2004～2008年间初治涂阳肺结核病人治疗失败的情况,为今后制定相应的防治对策提供科学依据。方法收集2004-2008年武鸣县结核病控制项目肺结核病人登记治疗资料并进行统计分析。结果2004～2008年间初治涂阳肺结核病人治疗失败率为2.9%,男性初治失败率高于女性,不规律治疗病人治疗失败率为7.9%明显高于规律治疗病人的2.4%(χ2=6.65,P<0.05),二月末痰涂片阴性病人治疗失败率,远低于二月末痰涂片阳性病人(χ2=56.9,P<0.001)。结论加强初治病人宣教,提高病人治疗依从性,对疗效不满意或二月末痰检仍阳性的初治病人,及时做结核菌培养及药敏试验,针对个体调整治疗方案,提高病人治愈率。
Objective To analyze the failure of newly-treated smear-positive pulmonary tuberculosis patients from 2004 to 2008 in Wuming County, Guangxi Province, and to provide a scientific basis for formulating appropriate control strategies in the future. Methods The data of tuberculosis patients’ registration and treatment in the Wuming County TB Control Project from 2004 to 2008 were collected and statistically analyzed. Results The treatment failure rate of smear-positive pulmonary tuberculosis patients was 2.9% between 2004 and 2008, and the failure rate was higher in males than in females. The treatment failure rate in patients with irregular treatment was 7.9%, significantly higher than that in regular therapy patients (χ2 = 6.65 , P <0.05). The failure rate of sputum smear-negative patients at the end of February was much lower than that of sputum smear-positive patients at the end of February (χ2 = 56.9, P <0.001). Conclusion To strengthen the education of patients with newly diagnosed patients, to improve patient compliance with treatment, the results are not satisfied with the end of February or sputum examination was still positive in patients with newly diagnosed tuberculosis and drug susceptibility testing, adjusting treatment for individual treatment to improve patient healing rate.