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本文对12例垂体泌乳素大腺瘤(直径>1cm)的治疗和随访作回顾性分析。单用溴隐亭治疗后,93%患者血清泌乳素(PRL)水平迅速下降,肿瘤明显缩小。除1例未婚,1例失访,2例因药物治疗无明显效果而改为手术治疗外,余8例均获足月妊娠。妊娠期间停用溴隐亭治疗,并无肿瘤生长过分活跃的征象。结果提示,单纯溴隐亭治疗对于垂体泌乳素大腺瘤也是相当有效的。当瘤体明显缩小后可允许妊娠,妊娠后即可安全地停药。分娩或哺乳停止后,则可根据肿瘤大小及临床表现继续给予溴隐亭治疗。
In this paper, 12 cases of pituitary prolactinoma (diameter> 1cm) treatment and follow-up for retrospective analysis. Serum prolactin (PRL) levels decreased rapidly in 93% of patients after treatment with bromocriptine, and the tumor was significantly reduced. Except one case was unmarried, one case was lost to follow-up, and two cases were treated surgically due to no obvious effect of drug treatment. All the remaining eight cases received full-term pregnancy. Bromocriptine was discontinued during pregnancy, with no signs of overabundance of tumor growth. The results suggest that simple bromocriptine therapy for pituitary prolactin large adenoma is also quite effective. When the tumor was significantly reduced to allow pregnancy, pregnancy can be safely stopped. After delivery or breastfeeding stopped, according to the size of the tumor and clinical manifestations continue to be given bromocriptine treatment.