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目的:观察不稳定性心绞痛患者(UAP)入院后血清肌钙蛋白I(cTnI)的变化,探讨UAP与心脏事件的近期、远期预测价值。方法:60例UAP患者分别在入院、入院后12h、24h、48h、10d各采血一次。用免疫发光法(IM-MULITE系统)测定cTnI浓度,分析其与心脏事件的关系。结果:在近期(30d)内,cTnI≥0.4ng/ml组与cTnI<0.4ng/ml组心脏事件发生率分别为48.15%和9.1%(P<0.05)。cTnI对近期发生心脏事件的阳性预测值48.15%,阴性预测值90.90%。远期:cTnI≥0.4ng/ml组病死率为18.52%(5/27);cTnI<0.4ng/ml组病死率为3.03%(1/33);(P<0.05)。结论:cTnI定量测定对UAP患者进行危险度分层有重要预测价值。
Objective: To observe the changes of serum cardiac troponin I (cTnI) in patients with unstable angina pectoris (UAP) after admission and to explore the short-term and long-term predictive value of UAP and cardiac events. Methods: Sixty UAP patients were admitted to hospital, 12h, 24h, 48h, 10d after admission. The concentration of cTnI was measured by immunoluminescence (IM-MULITE system), and its relationship with cardiac events was analyzed. Results: The incidence of cardiac events in cTnI≥0.4 ng / ml group and cTnI <0.4 ng / ml group was 48.15% and 9.1% (P <0.05) respectively in the short term (30 days). The positive predictive value of cTnI for the recent cardiac events was 48.15% and the negative predictive value was 90.90%. In the long term, the mortality of cTnI≥0.4ng / ml was 18.52% (5/27). The mortality of cTnI <0.4ng / ml was 3.03% (1/33) (P <0.05). Conclusion: The cTnI quantitative determination of UAP risk stratification has important prognostic value.