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下丘脑促性腺激素释放激素(GnRH)在哺乳类生殖调控中起关键性作用。虽然在1971年GnRH即被分离成功,确定了氨基酸序列,并能化学合成,但对其生物合成过程知之甚少。最近,由于cDNA技术的发展,已阐明GnRH基因结构及前体蛋白分子的一级结构,并发现另一裂解片段GnRH相关肽可抑制培养的大鼠垂体分泌催乳素。这一突破性进展,将大大促进GnRH生物合成及生
Hypothalamic gonadotropin-releasing hormone (GnRH) plays a key role in mammalian reproductive regulation. Although GnRH was successfully isolated in 1971, the amino acid sequence was determined and chemically synthesized, little was known about its biosynthesis process. Recently, due to the development of cDNA technology, the primary structure of the GnRH gene structure and the precursor protein molecule has been elucidated, and another cleavage fragment GnRH-related peptide has been found to inhibit the secretion of prolactin from the cultured rat pituitary gland. This breakthrough will greatly promote GnRH biosynthesis and health