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在不麻醉的正常血压大白鼠,腹腔注射利血平,每日0.5,1.0毫克/公斤,連給5天,对血压产生先升后降的双相反应。在血压改变的同时,心脏和腎上腺的儿茶酚胺含量也有明显的降低。升压的高峰期間,正与腎上腺和心脏中儿茶酚胺含量下降到最低点相符,但血压曲綫的从高峰下降,却同腎上腺中儿茶酚胺含量的趋向恢复相一致,而心脏儿茶酚胺曲綫則仍保持在最低的水平。升压后出現降压,其血压最低点恰恰落在心脏儿茶酚胺含量曲綫恢复前的最低点,当时腎上腺儿茶酚胺含量已經恢复一半上下。根据血压曲綫和两种組織儿茶酚胺含量曲綫在时間上的这种相互关系,可以认为在我們实驗条件下,利血平的升压作用可能主要由于腎上腺內儿茶酚胺的釋放,而降压作用則可能为心血管組織中儿茶酚胺耗竭的結果。
In non-anesthetized normotensive rats, intraperitoneal injection of reserpine, 0.5, 1.0 mg / kg daily, even for 5 days, the blood pressure first and then decreased diphasic response. At the same time as the blood pressure changes, the catecholamines in the heart and adrenal gland are also significantly reduced. During the peak boost period, the catecholamine levels in the adrenal gland and heart decreased to the lowest point, but the peak blood pressure curve decreased in line with the trend of adrenal catecholamine recovery, while the cardiac catecholamine curve remained at a minimum Level. Antihypertensive after the emergence of antihypertensive, the lowest point of its blood pressure falls precisely in the heart catecholamine content curve before the return to the lowest point, when the adrenal catecholamine levels have been restored up and down. Based on this correlation between blood pressure curves and the catecholamine profiles of the two tissues over time, it is believed that in our experimental conditions, the potentiation of reserpine may be mainly due to the release of catecholamines in the adrenal gland while the antihypertensive effect may be The result of catecholamine depletion in cardiovascular tissue.