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目的比较卡铂合并放疗与单纯放疗治疗中晚期食管癌的疗效及毒副作用。方法１９９０年８月～１９９２年１０月收治１９２例经病理证实为鳞癌的食管癌病人。病变长度为５－１０ｃｍ，随机配对分为两组，卡铂合并放疗组（卡铂组）与单纯放疗组（单放组）。结果卡铂合并放疗组近期疗效明显优于单纯放疗（Ｐ＜０．０５）。１、３、５年生存率，卡铂组分别为６１．５％、３０．２％、２５．０％；而单放组则为４１．７％（Ｐ＜０．０１）、２０．８％（Ｐ＞０．０５）、１６．７％（Ｐ＞０．０５）。毒副作用为轻度造血功能抑制与放射性食管炎。对症处理后不影响疗程。结论卡铂配合放疗治疗食管癌有协同作用。其毒副作用小，临床应用安全可行。
Objective To compare the efficacy and side effects of carboplatin combined with radiotherapy and radiotherapy alone in the treatment of advanced esophageal cancer. Methods From August 1990 to October 1992, 192 patients with esophageal cancer who were confirmed pathologically as squamous cell carcinoma were treated. The lesions were 5-10 cm in length and were randomly assigned to two groups: carboplatin plus radiotherapy (carboplatin) and radiotherapy alone (single radiotherapy). Results The short-term efficacy of carboplatin plus radiotherapy group was significantly better than that of radiotherapy alone (P<0.05). The 1-, 3-, and 5-year survival rates were 61.5%, 30.2%, and 25.0% in the carboplatin group, and 41.7% in the radiotherapy group (P<0.01), 20.8. % (P>0.05), 16.7% (P>0.05). The toxic side effects are mild hematopoietic function inhibition and radioactive esophagitis. Symptomatic treatment does not affect the course of treatment. Conclusion Carboplatin combined with radiotherapy has a synergistic effect on esophageal cancer. Its toxic side effects are small and clinical application is safe and feasible.