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目的探究颅咽管瘤组织中α-干扰素受体(IFN-αR)以及ADAMDEC1的表达及临床意义。方法 58例颅咽管瘤组织标本作为研究组,58例行脑肿瘤造瘘切除的正常脑组织标本作为对照组,测定两组IFN-αR以ADAMDEC1的表达并进行对比分析。结果研究组IFN-αR表达阳性率为100.0%,高于对照组的34.5%,差异具有统计学意义(P<0.05)。研究组ADAMDEC1、ADAMDEC1m RNA表达量高于对照组,差异具有统计学意义(P<0.05)。结论 IFN-αR以ADAMDEC1在颅咽管瘤组织中呈高表达特征,可以作为颅咽管瘤潜在病变的标志物而加以推广使用。
Objective To investigate the expression of α-interferon receptor (IFN-αR) and ADAMDEC1 in craniopharyngioma tissues and its clinical significance. Methods 58 cases of craniopharyngioma tissue samples were taken as the study group, 58 normal brain tumor fistula resected normal brain tissue samples were taken as the control group. The expression of IFN-αR in both groups were detected and compared. Results The positive rate of IFN-αR in study group was 100.0%, which was higher than that in control group (34.5%), the difference was statistically significant (P <0.05). The expression of ADAMDEC1 and ADAMDEC1m RNA in the study group was higher than that in the control group, with statistical significance (P <0.05). Conclusion IFN-αR is characterized by high expression of ADAMDEC1 in craniopharyngioma tissues and can be used as a marker of potential lesions of craniopharyngioma.