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目的观察尼可地尔(Nicorandil)及硝酸异山梨酯片治疗微血管性心绞痛的疗效比较。方法按入选标准,将河北省邢台市第三医院自2009年1月—2011年5月于该院诊断微血管性心绞痛患者100例,随机分为2组尼可地尔组(50例)、硝酸异山梨酯组(50例)。2组分别在使用β受体阻滞剂、钙离子拮抗剂及他汀类药物等药物基础上分别加用尼可地尔及硝酸异山梨酯片。观察患者服药3个月心绞痛发作次数、持续时间、显效率及常规心电图的ST-T改善情况。结果与硝酸异山梨酯组比较,尼可地尔组心绞痛发作次数减少(10±4.8 vs 13±6.1),差异有统计学意义(t=2.73,P<0.01);尼可地尔组心绞痛发作显效率明显高于硝酸异山梨酯组,差异有统计学意义(χ2=7.31,P<0.01);2组患者心电图异常改善效果,尼可以尔组优于硝酸异山梨酯组,差异有统计学意义(χ2=7.81,P<0.01)。结论尼可地尔对于冠状动脉微血管性心绞痛有效,且疗效优于硝酸异山梨酯片。
Objective To compare the efficacy of Nicorandil and isosorbide dinitrate in the treatment of angina pectoris. Methods According to the inclusion criteria, 100 patients with angina pectoris diagnosed in the Third Hospital of Xingtai City, Hebei Province from January 2009 to May 2011 were randomly divided into two groups (n = Isosorbide group (50 cases). 2 groups were treated with nicorandil and isosorbide dinitrate respectively on the basis of drugs such as β-blockers, calcium antagonists and statins. The patients were treated with 3 months angina pectoris episodes, duration, significant efficiency and conventional electrocardiogram ST-T improvement. Results Compared with isosorbide dinitrate group, the number of angina pectoris in nicorandil group decreased (10 ± 4.8 vs 13 ± 6.1), the difference was statistically significant (t = 2.73, P <0.01); angina pectoris occurred in nicorandil group Significantly higher efficiency was significantly higher than isosorbide dinitrate group, the difference was statistically significant (χ2 = 7.31, P <0.01); ECG abnormalities in two groups to improve the effect of nicorandil group is better than isosorbide dinitrate group, the difference was statistically significant Significance (χ2 = 7.81, P <0.01). Conclusions Nicorandil is effective in treating coronary angiocardiography and its effect is better than that of isosorbide dinitrate.