血清素引起的超极化促成猪冠状动脉的内皮依赖性舒张(英文)

• 作 者: Seung-Jung PARK Mikio NAKASHIMA Tetsuhiko NAGAO Paul M VANHOUTTE
• 机 构: Center for Experimental Therapeutics, Department of Medicine, Baylor College of Medicine, One Baylor
• 出 处: Acta Pharmacologica Sinica
• 发表日期: 1999年12期
• 关键词: 内皮依赖性 猪冠状动脉 血清素 钾通道 膜电压 酮色林 血管内皮 甲硫替平 吲哚美辛 endothelium

AIM: The present study was designed to investigatethe contribution of membrane hyperpolarization toendothelium-dependent relaxations induced by serotoninin the porcine coronary artery. METHODS: Ringswith and without endothelium of porcine coronaryarteries were suspended in conventional organ chambersfor the measurement of isometric force. The cellmembrane potential of the vascular smooth muscle cellswas measured using glass microelectrodes, in thepresence of indometacin, ketanserin, and/or N~ω-nitro-L-arginine. RESULTS: Serotonin induced a transi-ent endothelium-, and concentration-dependent relaxa-ti-n in rings contracted with prostaglandin F_(2α) in the

AIM: The present study was designed to investigate the contribution of membrane hyperpolarization to endothelium-dependent relaxations induced by serotoninin the porcine coronary artery. METHODS: Ringswith and without endothelium of porcine coronary artery strains were suspended in conventional organ chambers for the measurement of isometric force. The cell membrane potential of the vascular smooth muscle cells were measured using glass microelectrodes, in the presence of indometacin, ketanserin, and / or N ~ ω-nitro-L-arginine. RESULTS: Serotonin induced a transi-ent endothelium-, and concentration- dependent relaxa- ti-n in rings contracted with prostaglandin F_ (2α) in the