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目的探讨血清胱抑素C对窒息新生儿早期肾功能损害的诊断价值。方法采用胶乳增强免疫比浊法、脲酶电极法和苦味酸法分别测定16例重度窒息新生儿患者,20例轻度窒息新生儿患者,40例健康对照者的血清胱抑素C(CystatinC,CysC)、血清尿素氮(BUN)和血清肌酐(Scr)浓度,并对各组血清CysC、BUN和Scr进行比较分析。结果重度窒息新生儿组和轻度窒息新生儿组:CysC、BUN、Scr浓度明显高于正常对照组,有显著性差异(P均<0.01);CysC、BUN、Scr诊断窒息新生儿早期肾功能损害的敏感性分别为85.7%、61.4%、73.5%;特异性分别为92.1%、100%、100%;准确性分别为90.3%、79.2%、88.5%。结论与BUN和Scr相比,CysC是一个更敏感、准确地反映窒息新生儿早期肾功能损害的指标,对于诊断窒息新生儿早期肾功能损害具有重要意义。
Objective To investigate the value of serum cystatin C in the diagnosis of early renal dysfunction in neonates with asphyxia. Methods Serum levels of cystatin C (Cystatin C, CysC) were measured by latex enhanced immunoturbidimetry, urease electrode method and picric acid method in 16 neonates with severe asphyxia, 20 neonates with mild asphyxia and 40 healthy controls, respectively. ), Serum urea nitrogen (BUN) and serum creatinine (Scr) were measured. The levels of serum CysC, BUN and Scr in each group were compared. Results The levels of CysC, BUN and Scr in severe asphyxia neonatorum and mild asphyxia neonatorum were significantly higher than those in normal control group (all P <0.01). CysC, BUN and Scr were used to diagnose early renal function in neonates with asphyxia The sensitivities of the lesions were 85.7%, 61.4% and 73.5% respectively; the specificity were 92.1%, 100% and 100% respectively; the accuracy was 90.3%, 79.2% and 88.5% respectively. Conclusions Compared with BUN and Scr, CysC is a sensitive and accurate indicator of early renal dysfunction in neonates with asphyxia, which is of great significance for the diagnosis of early renal dysfunction in neonates with asphyxia.