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端粒是存在于染色体末端的富含Ｇ的ＤＮＡ重复序列，构成了ＤＮＡ末端的保护性的帽。端粒酶是一种核糖核蛋白，具有反转录酶活性，能以自身的ＲＮＡ为模板合成端粒序列。在正常体细胞中端粒酶无活性或仅表达低活性，在大多数永生细胞、恶性肿瘤细胞及生殖细胞中都存在端粒酶活
Telomeres are G-rich DNA repeats that exist at the end of a chromosome and form a protective cap at the end of the DNA. Telomerase is a ribonucleoprotein with reverse transcriptase activity and can synthesize telomere sequences using its own RNA as a template. Telomerase activity or only low activity in normal somatic cells, telomerase activity in most immortal cells, malignant tumor cells and germ cells