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原发性痛风在国内并不少见,且近年的发生率和发现率有增长的趋势。肾脏是痛风的主要靶器官,也是影响预后的主要因素之一。病理:痛风肾病以肾小管间质病变为著。尿酸PK为5.75,在pH>6的溶液中很快生成尿酸盐,因体液包括血液和滑膜液pH 为7.4左右,体内尿酸总以钠盐形式存在。少部分为钾盐。又因肾乳头部钠离子浓度比血浆高2～3倍,故此处较易析出尿酸钠结晶。所以慢性痛风肾病乳头和肾间质病变远较肾皮质显著。在急性发作期尿酸钠沉积,周围有炎症细胞浸润和巨噬细胞反应。嗣后有肾小球基膜增厚和纤维化,肾小管变
Primary gout is not uncommon in China, and the incidence and discovery rate in recent years have been increasing. Kidney is the main target organ of gout, but also one of the main factors that affect the prognosis. Pathology: Gout nephrosis with tubulointerstitial lesions. Uric acid PK of 5.75, in the solution of pH> 6 urate quickly, because of body fluids, including blood and synovial fluid pH of about 7.4, the total body uric acid in the form of sodium salt. A small part of the potassium salt. Because of renal papillary sodium ion concentration 2 to 3 times higher than plasma, it is easier to precipitate sodium urate crystals here. Therefore, chronic gout nephropathy nipple and renal interstitial lesions than the renal cortex significantly. In the acute phase of sodium urate deposition, surrounded by inflammatory cell infiltration and macrophage response. Followed by glomerular basement membrane thickening and fibrosis, tubular changes