论文部分内容阅读
茶碱的临床应用已有五十余年历史,被认为是一传统的治疗哮喘及慢性阻塞性肺疾患的药物。尽管发生过由于茶碱急性毒性反应导致患者死亡的意外,茶碱的应用曾一度下降,但近年随着对茶碱研究的深入,更随着茶碱血药浓度监测的开展,茶碱的应用趋于有效和安全,广泛用平喘治疗。由于茶碱的治疗指数狭窄、个体代谢差异大,复杂的药动学表现,及受多种药物的相互作用影响,发生茶碱过量者仍不少见。为合理使用茶碱,我们对近两年来本科茶碱过量患者的资料进行分析,初步探讨茶碱过量的时间分布及与剂量的关系,提供使用茶碱时参考。
Theophylline has been used for more than fifty years in clinical practice and is considered as a traditional medicine for the treatment of asthma and chronic obstructive pulmonary disease. In spite of the accidental death of patients caused by the acute toxicity of theophylline, the use of theophylline once dropped. However, with the further study on theophylline and the monitoring of theophylline concentration in recent years, the application of theophylline To be effective and safe, widely used asthma treatment. Due to the narrow therapeutic index of theophylline, individual metabolic differences, complex pharmacokinetic performance, and the interaction of many drugs, theophylline overweight are still not uncommon. In order to make proper use of theophylline, we analyzed the data of over-theophylline overdose patients in the past two years, and initially discussed the time distribution of theophylline excess and its relationship with the dosage, which provided a reference for theophylline use.