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异名 Livostin 化学名 (—)-[3S-[1(顺)3α,4β]]-1-[4-氰基-4-氟苯基)-环己基]-3-甲基-4-苯基-4-哌啶-羧酸盐酸盐药效分类抗组胺药上市厂商 (英)Janssen公司1991年上市药理本品与组胺H_1-受体位点有高选择性的亲和力,与位点的离解半减期为116分钟,表明离解率低;但与多巴胺受体的亲和力则明显较小,与组胺H_2-受体和5-羟色胺受体位点的亲和力更小。本品对神经递质胺类的再摄入无任何影响。初步的动物试验表明,本品即使剂量很小也能明显降低由组胺所致的豚鼠死亡率,对抗强效促肥大细胞脱颗粒剂引起的大鼠致命性休克。用豚鼠进一步试验证实,口服本品0.005mg/kg能特异性地抑制组胺气雾剂引
Synonyms Livostin Chemical Name (-) - [3S- [cis (3α, 4β]] - 1- [4-Cyano-4- fluorophenyl) -cyclohexyl] 4-piperidine-carboxylic acid hydrochloride Pharmacodynamic Category antihistamines listed companies (UK) Janssen company listed in 1991 Pharmacology This product has a high affinity with the histamine H_1-receptor sites, and bit The half-time of dissociation at point was 116 minutes, indicating a low dissociation rate; however, the affinity for dopamine receptors was significantly smaller with less affinity for the histamine H 2 -receptor and serotonin receptor sites. This product has no effect on the reuptake of neurotransmitter amines. Preliminary animal experiments show that the product even at a small dose can significantly reduce the mortality caused by histamine guinea pigs against powerful fat granulocyte degranulation induced fatal shock in rats. Further tests with guinea pigs confirmed that oral 0.005mg / kg of this product can specifically inhibit the histamine aerosol