1H nuclear magnetic resonance-based metabolomics reveals sex-specific metabolic changes of gastrodin

• 作 者: Xin Li Yuan-Wei Jia Jun-Song Wang Ming-Hua Yang Kelvin D G Wang Ling-Yi Kong
• 机 构: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmace
• 出 处: 亚太热带医药杂志（英文版）
• 发表日期: 2014年10期
• 关键词: Gastrodin Metabolomics 1H NMR spectroscopy Sex differences Health protection

Objective:To explore1H nuclear magnetic resonance-based metabolomics on sex-specific metabolic changes of gastrodin intervention in rats.Methods:In this research,1HNMR-based metabolomics was used for the first time to investigate metabolic changes following chronic intervention with gastrodin in rats.Results:24 endogenous metabolites were identified.Body weight, daily diet and the total volume of urine in in each day of each rat were measured synchronously.Modifications in12 metabolites were observed following gastrodin intervention, indicating gastrodin-induced alterations in carbohydrate and energy metabolism.Interestingly, these metabolic changes were not totally identical in female and male rats.Some metabolic changes arising from gastrodin intervention showed sexual dimorphism includingLDL/VLDL and lactate which were on the decrease in the female but on the increase in the male, together with arginine/ithine, creatine, and glycerol which were on the increase in the female but on the decrease in the male.While the decrease in pyruvate, succinate and glutamate was only shown in the male and the increase in valine,α-ketoglutarate, glycine and glucose was only in the female. Conclusions:This research shows the sex-specific metabolic response toGAS intervention, weatherGAS is a healthy dietary supplement for the male merits further investigation.