Promotion Mechanism of H2O for Stereoselectivity in Pd(Ⅱ)-catalyzed C—H Arylation of Diarylphosphina

• 作 者: CAI Yanchun JIAO Long QIU Xuepeng DU Zhijun
• 机 构: Polymer Composites Engineering Laboratory, Changchun Institute of Applied Chemistry,Chinese Academy
• 出 处: 高等学校化学研究（英文版）
• 发表日期: 2020年5期
• 关键词: C—H activation Stereoselectivity Water Ligand exchange

On the basis of a series of control experiments and nuclear magnetic resonance analyses,it is discovered that Boc-protected amino acid ligand coordinated to Pd center is partly replaced by N,N-dimethylformamide,and H2O can inhibit coordination of N,N-dimethylformamide to Pd center.The novel action mechanism perfectly explains H2O promotion for stereoselectivity in Pd(Ⅱ)-catalyzed C—H arylation of diarylphosphinamides with arylboronic acids.