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1976年 Cathcart 首先用皮质激素冲击疗法治疗进行性狼疮性肾病。成人一般用法为:每日静脉点滴甲基强的松龙1,000mg,连续3日;根据患者的反应,必要时至少间隔1周以上可再重复上述治疗。通常在冲击疗法后每日给予强的松龙40～60mg 作为后续疗法,并可比较迅速地减量。采用本疗法后2周,γ-球蛋白的半衰期(约为12天)呈几何级数缩短。这是因为系统性红斑狼疮(SLE)时γ-球蛋白的半衰期近2周,在此期间γ-球蛋白的产生几乎完全被抑制之故。抗 DNA 抗体效价和血清补体的改善也从早期开始出现。Lewinsky 曾报告血中免疫复合物显著减少。恒松氏等统计的日本厚生省胶原病治疗组的18例中,有效率为50～60%,其中多数以往的治疗效果
In 1976, Cathcart first used corticosteroid therapy for the treatment of progressive lupus nephropathy. Adult general usage is: daily intravenous methylprednisolone 1,000mg, 3 consecutive days; according to the patient’s response, if necessary, at least 1 week intervals above repeat the above treatment. Normally 40 to 60 mg of prednisolone is given daily after impact therapy as a follow-up and can be titrated relatively quickly. After 2 weeks of treatment, the half-life of gamma globulin (approximately 12 days) was reduced geometrically. This is because the half-life of gamma globulin in SLE is nearly two weeks, during which gamma-globulin production is almost completely inhibited. Anti-DNA antibody titers and improvements in serum complement also appeared early. Lewinsky has reported a significant decrease in immune complexes in the blood. Japan’s Ministry of Health, Japan’s collagen collagenosis treatment group 18 cases, the effective rate was 50 ~ 60%, of which the majority of the previous treatment