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目的检测Shh、Ptch在胃癌中的表达,分析其与临床病理特征的关系,探讨二者在胃癌发生发展的作用。方法采用免疫组化法检测116例胃癌、50例正常胃粘膜中Shh、Ptch的表达。结果 Shh和Ptch在胃癌中高表达,且与肿瘤直径、浸润深度、分化程度、淋巴结转移及预后相关(P<0.05)。二者表达呈正相关。结论 Shh和Ptch的表达上调可能与胃癌的发生发展有关,并起协同作用。
Objective To detect the expression of Shh and Ptch in gastric cancer and analyze the relationship between Shh and Ptch in clinicopathological features and to explore their roles in the development of gastric cancer. Methods Immunohistochemistry was used to detect the expression of Shh and Ptch in 116 cases of gastric cancer and 50 cases of normal gastric mucosa. Results Shh and Ptch were highly expressed in gastric cancer and correlated with tumor diameter, depth of invasion, differentiation degree, lymph node metastasis and prognosis (P <0.05). The two were positively correlated. Conclusion The up-regulation of Shh and Ptch may be related to the occurrence and development of gastric cancer and play a synergistic role.