论文部分内容阅读
目的了解新疆乌鲁木齐市某区抗结核药物所致的药物不良反应(Adverse Drug Reactions,ADRs)的主要类型及其发生率,并探讨其影响因素。方法选取新疆乌鲁木齐市某区结核病防治定点医院接受治疗的肺结核患者,对其随访至治疗结束,收集病例资料及治疗期间ADRs的发生情况,对其进行流行病学分析。结果 ADRs的总发生率为31.2%。多因素非条件logistic回归分析结果显示,老年、维吾尔族、追踪患者及管理方案中全程管理与ADRs的发生有关联(P<0.05),其OR值及95%CI分别为2.121(1.249~3.601)、0.259(0.123~0.545)、0.496(0.288~0.855)、0.205(0.051~0.829)。结论提倡全程督导管理方式,详细记录并观察肺结核患者在治疗期间ADRs发生情况,以便及时了解ADRs的发生和采取相应措施。
Objective To understand the main types and incidence of anti-TB drug-induced adverse drug reactions (ADRs) in a district of Urumqi, Xinjiang and to explore the influencing factors. Methods Pulmonary tuberculosis patients treated at TB control hospital in a certain area of Urumqi, Xinjiang were selected and their follow-up to the end of treatment, collection of case data and the occurrence of ADRs during the treatment were conducted, and their epidemiological analysis was conducted. Results The overall incidence of ADRs was 31.2%. Multivariate non-conditional logistic regression analysis showed that the overall management of ADRs in elderly, Uygur, tracing patients and management programs was associated with the occurrence of ADRs (P <0.05), and the OR and 95% CIs were 2.121 (1.249-3.601) , 0.259 (0.123 ~ 0.545), 0.496 (0.288 ~ 0.855), 0.205 (0.051 ~ 0.829). Conclusion Advocating full supervision and management, record and observe in detail the occurrence of ADRs in patients with pulmonary tuberculosis during treatment in order to keep abreast of the occurrence of ADRs and take corresponding measures.