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目的:观察厄贝沙坦治疗非杓型高血压患者降压效果及其杓型血压昼夜节律恢复情况,并观察治疗后血浆醛固酮水平的影响。方法:对杓型和非杓型两组原发性高血压患者分别给予150-300 mg/d,观察降压效果及对血压昼夜节律的影响,并监测用药前后血浆醛固酮水平的变化。结果:所有高血压患者应用厄贝沙坦治疗前后收缩压及舒张压均有不同程度的下降,非杓型组夜间收缩压及舒张压的下降值与杓型相比有统计学差异,出现了明显的昼夜节律,血浆醛固酮水平出现了明显差异。结论:厄贝沙坦对非杓型高血压患者有良好的降压作用,并能恢复非杓型高血压患者的昼夜节律,向杓型血压变化。
Objective: To observe the antihypertensive efficacy of irbesartan in non-dipper hypertensive patients and the recovery of diurnal rhythm of dipper blood pressure, and to observe the effect of plasma aldosterone level after treatment. Methods: The patients with dipper and non-dipper were treated with 150-300 mg / d respectively to observe the effects of antihypertensive effect on blood pressure and circadian rhythm, and to monitor the plasma aldosterone levels before and after treatment. Results: The systolic and diastolic blood pressure of all hypertensive patients before and after treatment with irbesartan decreased in varying degrees. The decrease of nocturnal SBP and diastolic blood pressure in non-dipper group was statistically different from that in dipper Significant circadian rhythm, plasma aldosterone levels showed significant differences. Conclusion: Irbesartan has a good antihypertensive effect on non-dipper hypertensive patients and can restore the circadian rhythm and the dipper blood pressure in non-dipper hypertensive patients.