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目的探讨研究支气管哮喘患者咽喉部位的菌群特征及其变化规律,为支气管哮喘的防治提供科学依据。方法选取某院收治的56例支气管哮喘患者作为病例组,同时选取50例健康人群作为对照组,分别对病例组和对照组患者咽喉部菌群进行检测分析,观察2组对象咽喉部菌群的结构、组成以及变化规律。同时,对分离出的病原菌进行抗生素药敏试验。结果病例组患者中需氧菌群和厌氧菌群的密度均高于对照组,差异有统计学意义(P0.05);同时,病例组与对照组咽喉部菌群均以需氧的链球菌、微球菌和奈瑟菌和厌氧的消化球菌、韦荣球菌以及类杆菌为主。对金黄色葡萄球菌、铜绿假单胞菌、肺炎克雷伯菌等病原菌的抗生素药敏试验结果表明,病例组的耐药情况高于对照组。结论支气管哮喘患者咽喉部菌群较健康人群菌群数量有大范围的增加,且病例组患者的病原菌耐药性高于对照组,但二者的菌群结构组成具有一定的相似性
Objective To investigate the characteristics of the flora in the throat of patients with bronchial asthma and its changes, so as to provide a scientific basis for the prevention and treatment of bronchial asthma. Methods Fifty-six patients with bronchial asthma were selected as the case group and 50 healthy people as the control group. The throat flora of the patients and the control group were detected and analyzed. The throat flora of the two groups were observed Structure, composition and variation. At the same time, antibiotics susceptibility test was carried out on the isolated pathogens. Results The density of aerobic and anaerobic groups in case group was higher than that in control group (P <0.05). At the same time, the throat flora in case group and control group were all with aerobic chain Cocci, Micrococcus and Neisseria and anaerobic peptococcus, Wei Rong cocci, and Bacteroides dominated. The results of antibiotic susceptibility tests on pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae showed that the drug resistance of the case group was higher than that of the control group. Conclusion The number of bacteria in the throat of patients with bronchial asthma has a wide range of increase compared with that of the healthy people, and the pathogenic bacteria resistance of the patients in the case group is higher than that of the control group. However, the flora composition of the two groups has some similarities