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目的观察脑血栓患者应用阿托伐他汀与抗血小板药联合治疗的临床效果及其对血小板参数的影响。方法随机选取我校2015-07-2016-07接受治疗的98例脑血栓患者,按照双盲均分原则将98例患者分为对照组与实验组,对照组49例患者给予常规治疗,实验组49例患者给予阿托伐他汀联合抗血小板治疗,比较两组患者临床治疗效果,以及血小板参数的变化。结果实验组患者有29例治疗显效,对照组有27例治疗显效,实验组患者临床治疗总有效率为95.9%,对照组总有效率为85.7%,两组患者治疗后全血粘稠度、血浆粘稠度、血小板粘附率、以及血沉的比例与治疗前有明显的改善,实验组患者改善幅度明显优于对照组。结论对于脑血栓患者在临床治疗的过程中给予阿托伐他汀联合抗血小板治疗,可以有效降低患者血液黏稠度,降低血小板的粘附性。
Objective To observe the clinical effect of combination of atorvastatin and antiplatelet drugs in patients with cerebral thrombosis and its influence on platelet parameters. Methods A total of 98 patients with cerebral thrombosis treated by our school from July 2015 to May 2016 were randomly divided into control group and experimental group according to the principle of double-blind sharing. 49 patients in control group were given routine treatment. The experimental group 49 patients were given atorvastatin combined antiplatelet therapy, the clinical efficacy of the two groups were compared, and changes in platelet parameters. Results The experimental group of patients treated with 29 cases markedly effective in the control group, 27 cases of treatment markedly effective in the experimental group clinical treatment of 95.9%, the control group, the total effective rate was 85.7%, the two groups of patients after treatment, the whole blood viscosity, Plasma viscosity, platelet adhesion rate, and the ratio of ESR were significantly improved before treatment. The improvement rate of the experimental group was significantly better than that of the control group. Conclusions In patients with cerebral thrombosis, atorvastatin combined with antiplatelet therapy can effectively reduce blood viscosity and reduce platelet adhesion during clinical treatment.