GAG-containing nucleotides as mediators of DNA-silver clusters and iron-DNA interplay

• 作 者: Tian-Tian Chen Qiu-Yun Chen Ming-Yang Liu
• 机 构: School of Chemistry and Chemical Engineering,Jiangsu University,State Key Laboratory of Coordination
• 出 处: Chinese Chemical Letters
• 发表日期: 2016年03期
• 关键词: silver DNA enhancer assembly template backbone titration mediator maxima conjuga

New types of fluorescence DNA-based silver nanoclusters(DNAn-Ag NCs, n = 1, 2, 3c, 4c, 5c) were synthesized by C3T-rich nucleotides as templates. It is found that the assembly of DNAn-Ag NCs with nucleotides containing GAG sequences produce silver clusters with an enhanced red emission. Results indicate that GAG is the good enhancer of DNAn-Ag NCs constructed by C3T-rich nucleotides. The fluorescence titration reveals that enhanced red emission is sensitive to Fe(III/II) ions with the formation of non-emission nanoclusters. Thus, the GAG-containing nucleotide can be an enhancer for the emission of silver clusters with C3T-rich nucleotide and a mediator of the iron-cluster interplay.

Novel types of fluorescence DNA-based silver nanoclusters (DNAn-Ag NCs, n = 1, 2, 3c, 4c, 5c) were synthesized by C3T-rich nucleotides as templates. It is found that the assembly of DNAn-Ag NCs with nucleotides Results indicate that GAG is the good enhancer of DNAn-Ag NCs constructed by C3T-rich nucleotides. The fluorescence titration reveals that enhanced red emission is sensitive to Fe (III / II) ions with the formation of non-emission nanoclusters. Thus, the GAG-containing nucleotide can be an enhancer for the emission of silver clusters with C3T-rich nucleotide and a mediator of the iron-cluster interplay.