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一般原理抗生素进入血循环后可能有四种结果:1.继续在血液中循环(游离,或与血清蛋白结合);2.外渗于周围组织,最后经由淋巴回复到大循环;3.由肝或肾排除;4.在周围病灶(感染区)或肝内降解,然后由尿或胆汗中排泄。表观分布容积可把药物的表观分布容积(AVD)当作循环外药物分布能力的近似值。这种表观分布容积指的是一定量的抗
General principles Antibiotics may enter the bloodstream after the four results may be: 1 continue to circulate in the blood (free, or with serum protein binding); 2 extravasation in the surrounding tissue, and finally by the lymphatic return to the general circulation; 3 by the liver or Renal exclusion; 4 in the surrounding lesion (infected area) or liver degradation, and then excreted by urine or biliary sweat. Apparent distribution volume can be the apparent volume of distribution of drugs (AVD) as an approximation of the distribution of drugs outside the loop. This apparent volume of distribution refers to a certain amount of resistance