论文部分内容阅读
大鼠颈上神经节的尾端和头端切断后，用免疫电镜方法研究节内P物质（SP）、降钙素基因相关肽（CGRP）免疫反应神经纤维的超微结构。尾端切断后，节内SP和CGRP免疫反应纤维数量比正常组明显减少，甚至消失。然而，头端切断后，该二种肽能神经数量则无明显变化。以此推测该节内SP、CGRP免疫反应神经纤维是节外起源。尾端切断后少数小强荧光细胞呈SP或CGRP免疫反应。SP阳性轴突与节后神经元紧密接触，但未见突触连结。SP阳性轴突与SP阴性反应树突构成对称性轴树突触。CGRP阳性轴突与阴性反应的小强荧光细胞构成轴体突触。讨论了大鼠颈上神经节内SP、CGRP免疫反应神经纤维的功能。
The ultrastructure of the immunoreactive nerve fibers of substance P (SP) and calcitonin gene related peptide (CGRP) were examined by immuno-electron microscopy after the tail and the head of rat superior cervical ganglion were cut off. After the tail was cut off, the number of SP and CGRP immunoreactive fibers in the joints was significantly reduced or even disappeared compared with the normal group. However, there was no significant change in the number of these two kinds of peptide nerves after the head was cut off. This speculated that the section of SP, CGRP immunoreactive nerve fibers are extra-nodal origin. A small number of small fluorescent cells after tail cutting showed SP or CGRP immune response. SP-positive axons and postganglionic neurons in close contact, but no synaptic connection. SP-positive axons and SP-negative reaction dendrites form symmetry axonal synapses. CGRP positive axons and negative reaction of small strong fluorescent cells constitute axonal synapses. The function of SP and CGRP immunoreactive nerve fibers in the superior cervical ganglia was discussed.