唾液及血清中糖类抗原CA-50测定对腮腺肿瘤的诊断价值

• 作 者: 曹剑鸣 宋建华 谢春 余丽丽
• 机 构: 昆明医学院第一附属医院
• 出 处: 云南医药
• 发表日期: 1998年06期
• 关键词: 腮腺肿瘤 CA-50 糖类抗原 肿瘤相关抗原 良性肿瘤组 涎腺肿瘤 口腔颌面部 双侧腮腺 含量测定 比邻关系

目的研究腮腺肿瘤患者腮腺液、全唾液及血清中糖类抗原ＣＡ－５０含量及其临床意义。方法对３０名正常人（对照组）；腮腺非肿瘤组１５例；腮腺良性肿瘤组２２例；腮腺恶性肿瘤组２７例，进行腮腺液、全唾液及血清中ＣＡ５０含量的测定。结果正常人血清、全唾液和腮腺液ＣＡ５０值分别为：８０２±４８ｕ／ｍ１、５７±６１ｕ／ｍ１、７８１±４２ｕ／ｍ１。全唾液ＣＡ５０值，恶性肿瘤组及患侧腮腺液ＣＡ５０明显高于其他各组（Ｐ＜００１），恶性组全唾液ＣＡ５０阳性率达９６５％（２６／２７），患侧腮腺液阳性率为９２６％（２５／２７）。结论全唾液或腮腺液ＣＡ５０含量测定对腮腺良、恶性肿瘤的鉴别具有较高参考价值，方法简例、无损伤，值得推广应用。

Objective To investigate the content and clinical significance of carbohydrate antigen CA-50 in salivary gland salivary glands, saliva and serum. Methods A total of 30 normal controls (control group), 15 non-neoplastic tumors, 22 benign tumors, and 27 parotid malignant tumors were used to determine CA50 in salivary glands, saliva, and serum. Results The serum CA50 values ​​of normal, whole saliva and salivary glands were 802±48u/m1, 57±61u/m1, and 781±42u/m1, respectively. CA50 value of saliva, malignant tumor group, and CA50 of parotid gland fluid in the affected side were significantly higher than those in other groups (P<001). The positive rate of CA50 in the malignant saliva was 965% (26/27), and the parotid gland fluid in the affected side. The positive rate was 92.6% (25/27). Conclusion The determination of CA50 in saliva or salivary gland fluid has high reference value for the differentiation of benign and malignant salivary gland tumors. The method is simple and non-invasive. It is worthy of popularization and application.