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作者采用前瞻性随机分组研究，自１９９３年１月～１９９４年９月，选用五联（ＨＤ－ＭＣＰ＋ＤＸＭ＋ＶｉｔＢ６＋６５４－２＋安定）、三联（ＨＤ－ＭＣＰ＋ＤＸＭ＋ＶｉｔＢ６）、二联（ＨＤ－ＭＣＰ＋ＤＸＭ）不同止呕吐方案，分别控制ＨＤ－ＰＤＤ水化治疗９０例晚期癌症病人引起的胃肠反应。结果：①五联、三联、二联组止呕吐率分别为：８０％、５５．６％、５１．２％，五联组与其它比较，Ｐ＜０．０１，有非常显著差异，三联与二联组比较，Ｐ＞０．０５，无明显差异；②合并胃病史者，五联、三联、二联组止呕吐率分别为：１５．４％、１０％、９．９％。上述结果示：五联药可能从不同环节同时阻断影响化疗引起胃肠反应的三个受体：多巴胺Ｄ２、组胺Ａ１、毒蕈硷类物质；合并胃病史，是影响止吐率的一个重要因素。五联组无一例椎体外系副反应，与应用６５４－２、安定有关。
The authors used a prospective randomized grouping study. From January 1993 to September 1994, five different emetics were selected: HD-MCP+DXM+VitB6+654-2+and diazepam, triplets (HD-MCP+DXM+VitB6), and dual-dose HD-MCP+DXM. Respectively control HD-PDD hydration to treat gastrointestinal reactions in 90 patients with advanced cancer. Results: 1 The rate of vomiting in the five-joint, triple-joint and double-joint groups was 80%, 55.6% and 51.2%, respectively. Compared with other groups, Wulian group had significant difference (P<0.01). Compared with the second group, P>0.05, no significant difference; 2 history of combined gastric disease, Wu Lian, Sanlian, Erlian combined vomiting rate were: 15.4%, 10%, 9.9%. The above results show that the five combined drugs may block three receptors that affect the gastrointestinal response induced by chemotherapy at the same time: dopamine D2, histamine A1, and toxins; the history of combined gastropathy is one of the factors that affect the antiemetic rate. Key factor. There was no case of extrapyramidal side effects in the Wulian group, which was related to the application of 654-2 and stability.