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目的:查找循证药学证据,解决临床用药问题,比较抗真菌药的有效性、安全性以及个体化用药。方法:通过对1例ICU肾移植术患者抗真菌治疗,检索数据库,查找相关的系统评价、随机对照试验等,并对所获得的证据进行质量评价。结果与结论:检索到系统评价3篇,安全性比较的随机对照试验1篇。各种抗真菌药的抗菌谱略有不同,各有特点,但是总体的病死率和反应率没有显著性差异,两性霉素B的不良反应率最高,棘白菌素类的不良反应率最低。临床药师根据患者特殊性和病情特点选择了合适的药物,疗效显著。
OBJECTIVE: To find evidence-based pharmacy evidence to solve the problem of clinical medication and to compare the effectiveness, safety and individualized anti-fungal drug use. Methods: An anti-fungal therapy was performed in 1 patient with ICU kidney transplantation, the database was searched, the related systematic reviews and randomized controlled trials were searched, and the quality of evidence obtained was evaluated. RESULTS AND CONCLUSION: Three systematic reviews were screened and one randomized controlled trial was compared for safety. The antibacterial spectrum of various antifungal agents is slightly different, each with its own characteristics, but the overall mortality and response rates were not significantly different, amphotericin B the highest adverse reaction rate, echinocandin the lowest adverse reaction rate. Clinical pharmacists according to the characteristics of the patient and the disease characteristics of the appropriate choice of drugs, the effect is significant.