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目的:比较珂立苏与固尔苏两种肺表面活性物质(PS)治疗新生儿呼吸窘迫综合症(NRDS)的临床疗效。方法:选择2011年2月～2012年12月在我院确诊并接受治疗的NRDS患儿58例,在患儿家长知情同意的情况下,随机分为A组(n=26例)和B组(n=32例)。在给予相同基础治疗措施的情况下,A组患儿采用珂立苏治疗,B组患儿采用固尔苏治疗,比较两组患儿治疗24 h后的机械通气参数与血气指标的变化,并比较两组患儿症状缓解时间、机械通气时间、吸氧治疗时间及住院时间。结果:治疗24 h后,两组患儿的呼气末正压(PEEP)、吸氧峰压(PIP)、平均气道压力(MAP)和氧浓度(FiO2)比较,均较治疗前显著降低,且B组以上指标均显著低于A组,差异均具有统计学意义(P<0.05);两组患儿的血PaO2和pH值均较治疗前显著升高,而血PaCO2、氧合指数(OI)均较治疗前显著降低,且B组血PaO2、pH值和OI均显著高于A组,而血PaCO2显著低于A组,差异具有统计学意义(P<0.05)。此外,B组患儿经治疗后的症状缓解时间、机械通气时间、吸氧治疗时间及住院时间均较A组患儿显著缩短,差异均具有统计学意义(P<0.05)。结论:积极给予固尔苏治疗NRDS,可促进患儿机械通气参数与血气指标的改善,并缩短临床治疗时间,其效果优于珂立苏。
OBJECTIVE: To compare the clinical efficacy of two drugs, namely clofibrate and celiac, in the treatment of neonatal respiratory distress syndrome (NRDS). Methods: 58 children with NRDS diagnosed and treated in our hospital from February 2011 to December 2012 were randomly divided into group A (n = 26) and group B with the informed consent of their parents (n = 32). Given the same basic treatment measures, the children in group A were treated with Ke Li Su, and the children in group B were treated with Guer Su Su. The changes of mechanical ventilation parameters and blood gas indexes were compared between the two groups after 24 hours of treatment The symptom relief time, mechanical ventilation time, oxygen therapy time and hospital stay in both groups were compared. Results: Compared with before treatment, PEEP, PIP, MAP and FiO2 in both groups were significantly lower after treatment for 24 h , And the above indexes in group B were significantly lower than those in group A (P <0.05). The blood PaO2 and pH in both groups were significantly higher than those before treatment, while the levels of PaCO2, oxygenation index (P <0.05). Compared with before treatment, the PaO 2, PaO 2 and PaCO 2 in group B were significantly lower than those in group A (P <0.05). In addition, the symptoms relieved time, mechanical ventilation time, oxygen treatment time and hospital stay in group B were significantly shorter than those in group A, the difference was statistically significant (P <0.05). CONCLUSIONS: The active treatment of NRT with Guer Su-Su can promote the improvement of mechanical ventilation parameters and blood gas indexes in children and shorten the clinical treatment time, which is superior to Ke Li Su.